Nou Camp - Champions League
Chelsea travel to Barcelona hoping to pull off a shock result and knock the Catalan side out of this season's Champions League.
Chelsea and Barcelona have shared some memorable battles in recent years, and the 1-1 draw at Stamford Bridge a fortnight ago stretches the Blues unbeaten run against Barcelona to eight games.
However they have never beaten Barcelona at the Nou Camp.
Chelsea's main injury doubt is over defender Antonio Rudiger, who is recovering from a thigh problem. He missed the weekend win over Crystal Palace and if he is not fit captain Gary Cahill will start alongside Cesar Azpilicueta and Andres Christensen.
David Luiz and Ross Barkley are both still out of action.
Lionel Messi was rested for Barcelona's weekend victory over Malaga, and will return for the visit of Chelsea, with the ineligible Philippe Coutinho set to miss out.
Andres Iniesta is likely to miss out through injury, and defender Sergi Roberto is also a doubt, with Lucas Digne and Paulinho on stand by.
Barcelona v Chelsea Preview and Predictions
Barcelona have been in sensational form this season, setting a record of 28 games unbeaten to start a La Liga season, and they have only been beaten once all season - by rivals Espanyol in the Copa del Rey.
Antonio Conte's Chelsea have suffered some big hits in recent weeks, despite their win over Palace at the weekend, they have lost to Manchester United, Manchester City, Watford and Bournemouth this month.
They face a real battle to secure a top finish, and their priorities could well be elsewhere on Wednesday night, whereas Barcelona almost have La Liga sown up.
Barcelona's dominance this season points to a win for them, priced at 4/7 and Conte's job could be on the line if that is the case.
Games between these two sides are normally tight, with more than two goals scored in just one of their last five meetings, and with that in mind an under 2.5 goals bet is 13/10.
Barcelona to win 2-0 at
With the Spanish title almost confirmed for Ernesto Valverde's side, they are likely to turn their attention to Europe and the trophy they have won five times. The forward line of Messi, Luis Suarez and Ousmane Dembele will cause problems for a Chelsea defence that has been exposed by both Manchester in recent weeks.
Lionel Messi to score first at
Talisman Messi will be firing all cylinders after a weekend rest, and with 34 goals already this season, he looks set for another magnificent campaign. He broke his nine-goal duck against Chelsea in the first leg, and he looks to be in the mood for more in Catalonia.