Arena do Gremio - Copa America
Brazil eased the pressure on themselves with strong end to the group stages, and will be hopeful of getting past Paraguay into the Copa America semi finals.
Brazil are unbeaten in their last five meetings with Paraguay, including a 3-0 win in their most recent game, in 2018 World Cup qualification.
However those results only tell part of the story, as La Selecao have lost two of those games on penalties, both in the Copa America.
Brazilian manager Tite has no fresh injury worries ahead of their last 16 tie, although he could look to rotate his starting XI, with David Neres or Richarlison likely to come back in for Everton - who scored in the 5-0 win against Peru.
Paraguay could recall striker Federico Santander, after he was rested for their final group game against Colombia, with midfielder Matias Rojas potential missing out with a knee injury.
Brazil v Paraguay Preview and Predictions
Brazil were under pressure to enter the knockout stages on a high, and they certainly did that with a 5-0 hammering of Peru - to re-establish their status as firm favourites to go on and win the competition on home soil in the coming weeks. Tite changed his side for their final group game, but he is expected to go all out in this clash, with Premier League trio Roberto Firmino, Richarlison and Willian all potentially starting against Juan Carlos Osario's side in the round of last 16.
Paraguay sneaked into the knockout stages as one of two of the best third placed sides, and Osario's side have not even won a game in this year's competition, with draws against Qatar and Argentina, and a final group game loss to Colombia. They will face a real battle against the host nation, as their best performances in the competition so far have been based on frustrating more technical opponents, as was the case against Lionel Messi's Argentina, on Match Day Two.
Brazil showed their attacking talent in that win over Peru, but Paraguay have proven themselves to be a tough nut to crack and a strong option for this game is Brazil to win, with under 2.5 total goals scored, which comes in at 2/1. Brazil have been slow starters in games so far in the competition, with no goals in their first two games in the competition, and they will be up against a Paraguayan wall in this tie in Gremio.
With that in mind, Tite's side will have to be patient in this game and first half draw/second half Brazil win is available for a tempting price of 13/5.
Brazil to win 2-0 at 4/1
Despite pressure from the fans, Brazil's players will likely have to probe and wait for a breakthrough against a Paraguay side that will look to stifle them, and they will look at their star players to look to make the difference as the game progresses.
Philippe Coutinho to score anytime at 7/5
The Barcelona forward has been key for Brazil so far, scoring twice in the opening game win over Bolivia. That intervention was vital, coming at a time when the fans were starting to become frustrated, and in a game that is likely to be slow, the former Liverpool could be the one to edge it for Brazil.