Etihad Stadium - Premier League
Manchester City host Tottenham for second time in four days - following their blockbuster Champions League clash with Tottenham emerging victorious.
Manchester City beat Spurs 4-3 on the night, but it was Tottenham that progressed into the Champions League semi finals for the first time in their history.
Spurs' 1-0 win in the first leg secured their spot in the last four via away goals, with City winning four of their last five meetings prior to a week ago.
City suffered no fresh injuries in the quarter final clash, however Alexander Zinchenko is still out, with Bernard Mendy expected to continue in his place. Fernandinho and John Stones could also come in, as Pep Guardiola rotates his side for the continuing title challenge.
Spurs lost Moussa Sissoko in the game at the Etihad in midweek, and he will join Eric Dier and Harry Kane on the treatment table, however Harry Winks is expected to come back into the side.
Manchester City v Tottenham Preview and Predictions
City saw their quadruple dream extinguished by Mauricio Pochettino's side in midweek in a classic battle, but it is back to the bread and butter of Premier League action this weekend for both sides. How this game goes will depend on how City react to that loss - and experience indicates that Guardiola will have his players ready to let rip on their European conquerors.
Spurs are still right in middle of a race to finish in the top four, with their league form slipping in recent weeks, meaning their position is far from safe. Two wins form their last four league games is far from ideal preparation for a busy run of games between now and the end of the season, and their response to their huge win will also be decisive.
The sense here is that with Europe now off their schedule, Guardiola's City will be focused on their goal of defending their league title - and a home win is t 1/4. This game is unlikely to have anywhere near the excitement of Wednesday night, but Spurs will again pose a real threat - and a BTTS bet comes in at 4/5.
Manchester City to win 2-1 at 15/2
City have to win to keep the pressure on Liverpool in this pulsating title race, and a victory would put them about Jurgen Klopp's side for at least 24 hours. Spurs will still be confident of securing a top four spot, but those points will come from their final games off the campaign.
Raheem Sterling to score anytime at 10/11
Sterling is in brilliant form at the moment, despite is late goal being ruled out through VAR in midweek. The former Liverpool man has 17 Premier League goals in 2018-19, and he has netted four goals in his last two games ahead of this weekend.