Arena Fonte Nova - Copa America
Uruguay have emerged as dark horses to win this game, and Oscar Tabarez's side will be hungry for a place in the semi final with a win over Peru.
Peru beat Uruguay 2-1 in qualification for the 2018 World Cup, with Tabarez's side winning the reverse fixture at Montevideo.
Despite winning the most recent meeting between the two sides, that was Peru's first win over Uruguay in their previous six games.
Tabarez could make a few team rotations for this clash, with midfielder Nicolas Lodeiro set to miss out, with Nahitan Nandez and Diego Laxalt pushing for a recall, after missing out on their final group stage 1-0 defeat to rivals Chile.
Defender Carlos Zambrano could make a return for Peru, after missing their final group game loss to Brazil, with midfielder Edison Flores also likely to come back in, with Miguel Araujo and Yoshimar Yotun the two players potentially missing out.
Uruguay v Peru Preview and Predictions
Tabarez will be happy with his side's progress in the competition so far, despite that defeat to Chile, and they have been handed a more favourable last 16 draw than some of their rivals - with Chile facing Colombia 24 hourrs before this game. Uruguay's strength at the two ends of the pitch means they will always be amongst the favourites to go far in tournaments, and their slow burner status will help ease the pressure on players that prefer an underdog title in big games.
Peru progressed into the last 16 by virtue of finishing as one of the best third placed sides, behind home nation Brazil and an impressive Venezuela, and they have have shown some signs of life in a 3-1 win over Bolivia and a battling 0-0 draw with Venezuela. However, their 5-0 drubbing by Brazil in their group game could be decisive in this clash. Ricardo Gareca's side were expected to lose to Tite's Brazil, but the weight of conceding five goals will weigh heavy on them up against a strong Uruguayan attack.
Uruguay have been unusually attack minded so far in the tournament, scoring six goals in their opening two games, against Ecuador and Japan, and they will be looking to keep that momentum going with a win here - priced at 8/11. Both of those games saw a strong 90 minute performance from Uruguay, with goals in both halves, and they are priced at 12/5 to score in both halves against Gareca's side.
Uruguay to win 2-0 at 6/1
Uruguay are now up to third favourites to win the competition, behind Brazil and Argentina, and a strong showing here could see them edge ahead of Lionel Scaloni's side, particularly as they will avoid both sides until a potential final in Rio de Janeiro.
Luis Suarez to score anytime at 20/21
Uruguay's all time leading scorer has looked fit and sharp in the competition so far, following his return from knee surgery, and he found the net against both Ecuador and Japan, and he will be wanting to push Tabarez's side on to the last four. The Barcelona striker is also the current favourite to finish the tournament as top scorer, at 5/1, ahead of club team mate Lionel Messi and international colleague Edinson Cavani.